Two sample MR report
JAML_Alveolar Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.2624321 | 0.1118544 | 0.0788425 |
| Weighted median | 6 | 0.0958683 | 0.0200140 | 0.0000017 |
| Inverse variance weighted | 6 | 0.0922819 | 0.0140921 | 0.0000000 |
| Simple mode | 6 | 0.1225067 | 0.0322084 | 0.0125826 |
| Weighted mode | 6 | 0.1216749 | 0.0284416 | 0.0078781 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.461190 | 4 | 0.6515986 |
| Inverse variance weighted | 4.812488 | 5 | 0.4391905 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1051387 | 0.068566 | 0.1999556 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001124 | 1e-07 | TRUE | 0.323225 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
